The sorting protein GASP-1 regulates the constitutive signaling capacity of the virally encoded chemokine receptor US28
نویسندگان
چکیده
Address: 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria , 2Ernest Gallo Clinic and Research Center, University of California San Francisco, CA 94608, USA, 3Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Faculty of Sciences, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands and 4Department of Dermatology, Medical University of Graz, 8036 Graz, Austria
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The role of GASP in the post-endocytic sorting and signaling of virally encoded chemokine receptor US28
Human cytomegalovirus, which infects up to 80% of the general population, causes severe complications in immunocompromised patients and is thought to be linked to vascular diseases, such as atherosclerosis and restenosis. This β-herpesvirus encodes a G protein-coupled receptor (GPCR), namely US28, which does not only show homology to endogenous chemokine receptors but also binds endogenous CC c...
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